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Department Of Chemistry

DEPARTMENTS

Engineering

Science

CENTRE

Dr. Nagendra Nath Yadav

Assistant Professor

Total synthesis of natural products, Development of new synthetic methodology and their application for the synthesis of biologically active molecules, asymmetric synthesis, medicinal chemistry, bio-organic chemistry, drug discovery, API (Active Pharmaceutical Ingredient) synthesis, process research and development, green chemistry, aziridine chemistry.

Contact
(EPBX/Office): +91-360-2257401 to 408; Ext. 7134
PROFESSIONAL BACKGROUND
FromToDesignationOrganisation
Novemver, 2016Till dateAssistant ProfessorNERIST (Deemed-to-be-University Under MoE, Govt. of India)
March, 2015October 2016Post-doctoral Research Assistant  (Supervisor – Prof. Hyun-Joon Ha)Hankuk University of Foreign Studies, Yongin, Korea
April, 2013February 2015Research ScientistProcess Research & Development Division, Sai Life Sciences Ltd., Hyderabad, India
March 2012March 2013Junior  Research ScientistResearch & Development Division, Biophore Pharma Ltd., Hyderabad, India
HONORS AND AWARDS
AwardInstituteYear
Postdoctoral Research FellowshipHankuk University of Foreign Studies, Yongin, Korea      2015
Inspire FacultyDepartment of Science & Technology (DST), New Delhi, India      2012
Senior Research Fellowship (SRF)Council for Scientific and Industrial Research (CSIR), New Delhi, India      2008
Junior Research Fellowship (JRF)Council for Scientific and Industrial Research (CSIR), New Delhi, India      2006
Graduate Aptitude Test in Engineering (GATE)IIT Kharagpur (MHRD, India)      2006
EDUCATIONAL DETAILS
DegreeSubjectUniversityYear
Ph.D  ChemistryIndian Institute of Chemical Technology (IICT)/ JNTU, Hyderabad, India (Supervisor: Dr. J. S. Yadav)2014  
M.Sc.Chemistry (Organic)DDU Gorakhpur University2005
ADMINISTRATIVE BACKGROUND
FromToDesignationOrganisation
July 2018Till dateLab Incharge PG Lab-IINERIST
March 2021Till date
Lab Incharge PG Lab-I
NERIST
SPONSORED RESEARCH PROJECTS
TopicFunding AgencyYear
   
MEMBERSHIPS IN PROFESSIONAL BODIES

TEACHING ENGAGEMENTS
TitleCourse CodeModuleSemester
Biochemistry    CY 3203B. Sc. (Forestry) 1st Year         II
Application of Spectroscopy to Organic Molecules    CY 8004M. Sc. 2nd Year         I
Natural Products    CY 8006M. Sc. 2nd Year         I
Organic Chemistry Lab    CY 8152M. Sc. 2nd Year         I
Chemistry 2    CY 11201Base 1st Year
Chemistry 2 Lab    CY 1201Base         II     
Organic  Synthesis    CY 8017M. Sc. 2nd Year         II
Project Work    CY 8299M. Sc. 2nd Year         II
PROJECTS AND THESIS SUPERVISED/ CURRENTLY SUPERVISING
Title of ProjectNames of Students
Synthesis of Protected Glucose DerivativesMr. Partha P. Nath
Synthesis of Various ortho-Allyl Phenols via Claisen RearrangementMs. Pompy Pokhrel
Activation of Quinoline/Isoquinoline for rhe Synthesis of Various Dihydro quinoline/ Isoquinoline derivativesMr. Hannan Uddin
Synthesis of three membered azaheterocycle Aziridine and its Opening ReactionMr. Monuranjan Gogoi
Synthesis of key starting material for Natural Products having Deoxypropionate SkeletonMr. Pranjit Saikia
Preparation of Iodine based oxidising agent and its application in Organic SynthesisMr. Rinku Dihingia
Study of stabilised and non-stabilised phosphonium ylides and synthesis of alkene by Wittig reactionMr. Prafulla Kaman
Preparation of Pyridine based oxidising agents and its application in oxidation reactionMs. Mandita Devi
Three-Component Coupling of Isoquinoline/Quinoline, Dimethyl Acetylenedicarboxylate (DMAD) and Reactive Methylene Compound: A Facile Synthesis of Dihydroisoquinoline/Quinoline DerivativeMs. Rekhajyoti Phukan
Synthesis of Chiral Aziridine and Nucleophilic Ring Opening with Anisole and ImidazoleMr. Nabin Sharma
Synthesis of Chiral Aziridine and Its Ring Opening Reaction with IndoleMr. Hirak Jyoti Bhuyan
Synthesis of Morita-Baylis-Hillman Acetate from P-Nitrobenzaldehyde and Its Substitution Reaction with Active Methylene CompoundsMr. Abhimanyu Nayak
Synthesis of acetate adducts of Baylis-Hillman reaction and Its Reaction with Active Methylene CompoundsMr. Wrishav Rajkhowa
Synthesis of Non-activated Aziridine and Its Ring Opening Reaction with 2-MethylIndoleMr. Debasish Baruah
Synthesis of Morita Baylis-Hillman Acetate from Unsubstituted Aromatic Aldehyde and Its Substitution Reaction with AnilineMrs. Kalyanee Kalita
Reaction of Morita-Baylis Hillman Acetate with Pyrazolone as Nucleophile: Regioselective Synthesis of 5-HydroxypyrazolesMs. Tupu Narzary
Reaction of Morita Baylis-Hillman Acetate with Sodium p-Toluenesulfinate: Regioselective Synthesis of Tosyl Substituted AcrylatesMr. Tenzin Palden
PHDS SUPERVISED
TopicScholar NameStatus of PHDRegistration Year
Synthesis of Natural Products from Chiral aziridine and Development of new Synthetic MethodologiesMrs. Archana PareekThesis Submitted2017
Synthesis of Piperidine Ring System and Development of New Synthetic MethodsMr. Sonam Tashi KhomThesis Submitted2018
Synthesis of Piperidine alkaloids from Aziridine and development of new synthetic methodsMr. Pranjit SaikiaOngoing2021
PARTICIPATION IN SHORT TERM COURSES
Course NameSponsored ByDate
15th Division of Organic Chemistry (branch organic chemistry) Summer Workshop on NMR Spectroscopy, Geoje, KoreaKorean Chemical SocietyAugust 24-25, 2015
“Pedagogy Training for Outcome Based Education”, at NERISTNITTTR BhopalMarch 16-17, 2017
Workshop on the Role of Local Chapters, at NERISTIIT KanpurApril 29, 2017
Short term course on “Leadership and Team Building in Academia” at NERISTNITTTR – KolkataOct 30 to Nov 03, 2017
One week Faculty Development Programme on “DSP & SENSORS”Electronics and ICT Acedemics, Government of IndiaDecember 10-14, 2018
Four week Orientation programme at UGC HRDC DDU Gorakhpur University GorakhpurUGC HRDC DDU Gorakhpur UniversityJan 15 to Feb 11, 2019
One week Faculty Development Programme on topic “Network Security” at NERISTElectronics and ICT Academy IIT GuwahatiMay 20-24, 2019
One week Faculty Development Programme on topic “Deep Learning and Applications” at NERISTElectronics and ICT Academy IIT GuwahatiMay 27-31, 2019
One week Faculty Development Programme on topic “Anteena Trends” at NERISTElectronics and ICT Academy IIT GuwahatiJuly 01-05, 2019
Two week Faculty Development Programme on “Impact of Climate change on Water Resources” at NERISTNERIST, Nirjuli, Arunachal PradeshOctober 14-25, 2019
One week Faculty Development Programme on topic “ICT Tools for Teaching, Learning Process & Institutes” at NERISTElectronics and ICT AcademyJanuary 13-17, 2020
Training Programme on topic “National Level Training Programme on DISASTER MANAGEMENT” at NERISTNational Institute of Disaster ManagementFebruary 27-29, 2020
One week online Faculty Development Programme on topic “Energy and Environment: Conversion, generation, storage and efficient utilization”Dept. of EE and CE, NERISTAugust 24-28, 2020
Online Training Programme on Digital tools for Writing, Authoring & Reviewing ManuscriptsElectronics & ICT Academies, MNIT Jaipur, NIT Patna & IIT GuwahatiSeptember 21 to October 02, 2020
Two week UGC sponsored refresher course in ChemistryChemistry Department, DDU Gorakhpur University, GorakhpurSeptember 11-24, 2021
One week online Faculty Development Programme on topic “Inculcating Universal Human Values in Technical Education”All India Council for Technical Education (AICTE)October 4 - 8, 2021
 NPTEL-SWAYAMJan-Apr 2021
PUBLICATIONS

International Journals:

  1. Khom, S. T.; Saikia, P.; Yadav, N. N. (Facile synthesis of 3-amino substituted piperidines from L-glutamic acid) Indian Journal of Chemistry 2024, 63, 518 –523.
  2. Pareek, A.;Khom, S. T.; Saikia, P.; Yadav, N. N. (A short and efficient Formal Synthesis of R-Pipecolic Acid from the Ring expansion of Chiral Aziridine) Monatsh Chem 2024, 155, 525-529.
  3. Khom, S. T.; Saikia, P.; Muzaddadi, I. U.; Murugan, A.; Yadav, N. N. (Synthesis of allylamines from Baylis–Hillman acetates using DBU under solvent free condition) Monatsh Chem 2023, 154, 865-871.
  4. V. Thandiayyakone, , A. Murugan, Ijaz U. Muzaddadi, , N. Tayum, , N. N. Yadav, , Pranjit Saikia, , T. Rajkumar, , A. Manohar, M. Chakrabarty (Effects of SbCl5, Ethylamine, Imidazole and 2-Methylimidazole on Redox and Structural Behaviours of Manganese(III) meso-5,10,15,20-tetrakis(4-pyridyl)porphyrin) Asian Journal of Chemistry 2023, 35, 1714-1718.
  5. Suryachandra, D. K.; Tenneti, S.; Yadav, N. N.; Yadav, J. S. (Stereoselective synthesis of C1-C11 fragment of antitumor cyclodepsipeptide (–)-doliculide) Indian Journal of Chemistry 2020,59B, 376 –384.
  6. Yadav, N. N.; Lee, Y.-G.; Srivastava, N.; Ha, H.-J. (Alkylative Ring-Opening of Bicyclic Aziridinium Ion and Its Application for Alkaloid Synthesis) Frontiers in Chemistry 2019, (7), doi: 10.3389/fchem.2019.00460
  7. Yadav, N. N.; Ha, H.-J.; “Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles”  J. Vis. Exp. (138), e57572, doi:10.3791/57572 (2018)
  8. Yadav, N. N.; Jeong, H; Ha, H.-J.; “Atom-Economical and Metal-Free Synthesis of Multisubstituted Furans from Intramolecular Aziridine Ring Opening” ACS Omega 2017, 2, 7525−7531.
  9. Choi, J.; Yadav, N. N.; Ha, H.-J.; “Preparation of a Stable Bicyclic Aziridinium Ion and Its Ring Expansion toward Piperidine and Azepane”, Asian J. Org. Chem. 2017, 6, 1292 –1307.
  10. Jeong, H; Yadav, N. N.; Ha, H.-J.; “Synthesis of Lacosamide (Vimpat) and Its Derivatives from Aziridine-(2R)-carboxylate”,  SYNTHESIS 2016, 49, 1264–1272.
  11. Yadav, N. N.; Dolfen, J.; Kimpe, N. D.; D’hooghe, M.; Ha, H.-J.; “Bicyclic Aziridinium Ions in Azaheterocyclic Chemistry – Preparation and Synthetic Application of 1-Azoniabicyclo[n.1.0]alkanes”, Adv. Synth. Catal. 2016, 358, 3485–3511.
  12. Yadav, N. N.; Choi, J.; Ha, H.-J.; “One-pot multiple reactions: asymmetric synthesis of 2,6-cis-disubstituted piperidine alkaloids from chiral aziridine”, Org. Biomol. Chem., 2016, 14, 6426-6434.
  13. Yadav, J. S.; Yadav, N. N.; Reddy, B. V. S.; “Studies directed towards the total synthesis of polyether antibiotic ionomycin: asymmetric synthesis of fragments C(24)-C(32) and C(1)-C(23)”, Tetrahedron 2015, 71, 7539-7549.
  14. Yadav, J. S.; Yadav, N. N.; Gupta, M. K., Srivastava, N.; Reddy, B. V. S.; “GaCl3-catalyzed activation of alkynyl glycosides for the synthesis of O-glycosides”, Monatsh Chem 2014, 145, 517-520.
  15. Yadav, J. S.; Yadav, N. N.; “An iterative, facile stereoselective synthesis of C1-C11 fragment of borrelidin via enzymatic desymmetrization strategy”, RSC Advances, 2013, 3, 4024-4032.
  16. Yadav, J. S.; Chary, D. N.; Yadav, N. N.; Sengupta, S.; Reddy, B. V. S. (Enantioselective Total Synthesis of Siphonarienal, Siphonarienone and Pectinatone) Helvetica Chimica Acta2013, 96, 1968–1977
  17. Yadav, J. S.; Sengupta, S.; Yadav, N. N.; Chary, D. N.; Ghamdi, A. A.; “Stereoselective synthesis of methyl branched chiral deoxypropionate units: A new route for synthesis of insect pheromone (−)-lardolure and (2R,4R,6R,8R) 2,4,6,8-tetramethylundecanoic acid”, Tetrahedron Lett. 2012, 53, 5952–5954.
  18. Yadav, J. S.; Rao, T.S.; Yadav, N. N.; Rao, K. V. R.; Reddy, B. V. S.; Ghamdi, A. K.; “Chemoenzymatic Approach to the Total Synthesis of (+)-Bourgeanic Acid”, SYNTHESIS 2012, 44(5), 788-792.
  19. Reddy, B. V. S.; Yadav, N. N.; Srivastava, N.; Yadav, J. S.; Sridhar, B.; “1,4-Dipolar cycloaddition reactions in ionic liquids: a facile synthesis of 9aH 15H-[1]Benzopyrano[3’,2’:3,4]pyrido[2,1-a]isoquinolines(=9aH 15HBenzo[a][1]benzopyrano [2,3-h]quinolizines”, Helvetica Chim. Acta 2012, 95, 76–86.
  20. Yadav, J. S.; Yadav, N. N.; Rao, T. S.; Reddy, B. V. S.; Ghamdi, A. K.; “Enantioselective total synthesis of (+)-vittatalactone”, Eur. J. Org. Chem. 2011, 4603–4608.
  21. Yadav, J. S.; Gupta, M. K.; Jain, R.; Yadav, N. N.; Reddy, B. V. S.; “A practical synthesis of bis(indolyl)methanes employing boric acid”, Monatsh Chem 2010, 141, 1001-1004.
  22. Yadav, J. S.; Reddy, B. V. S.; Yadav, N. N.; Gupta, M. K.; “Three component coupling of isoquinoline, activated alkyne and nitromethane: an expedient synthesis of nitroalkyl substituted 1, 2-dihydroIsoqunoline”, SYNTHESIS 2009, 1131-1136.
  23. Yadav, J. S.; Reddy, B. V. S.; Yadav, N. N.; Singh, A. P.; Choudhary, M.; Kunwar, A. C.; “Indium-mediated alkynylation of the Baylis-Hillman acetates: a novel route for 1,4-enynes”, Tetrahedron Lett. 2008, 49, 6090–6094.
  24. Yadav, J. S.; Reddy, B. V. S.; Yadav, N. N.; Gupta, M. K.; Sridhar, B.; “Gold(III) chloride catalyzed three-component reaction: a facile synthesis of alkynyl derivatives of 1,2-dihydroquinolines and isoquinolines”, J. Org. Chem. 2008, 73, 6857–6859.
  25. Yadav, J. S.; Reddy, B. V. S.; Yadav, N. N.; Gupta, M. K.; “Three-component coupling reactions of isoquinolines, dialkyl acetylenedicarboxylate and indoles: a facile synthesis of 3-indolyl-1,2-dihydro-2-isoquinolinyl-2-butenedioate”, Tetrahedron Lett. 2008, 49, 2815-2819.
  26. Yadav, J. S.; Reddy, B. V. S.; Yadav, N. N.; Satheesh, G.; “Aluminium(III)-promoted Prins-cyclization of 2-allylphenols: an expedient synthesis of benzoxepines”, SYNTHESIS 2008, 2733-2738.

National Journals:

International Conferences

MISCELLANEOUS

Paper presented at international conferences